And consolidating

After Molaison underwent a bilateral medial temporal lobe resection to alleviate epileptic symptoms the patient began to suffer from memory impairments.

Meanwhile, neuropharmacological studies of selected brain areas began to shed light on the molecules possibly responsible for fast consolidation.Specifically, NMDA-receptor antagonists appear to block the induction of both LTP and fear conditioning and that fear conditioning increases amygdaloidal synaptic transmission that would result in LTP.Synaptic consolidation, when compared to systems consolidation (which is said to take weeks to months to years to be accomplished), is considerably faster.In recent decades, advancements in cellular preparations, molecular biology, and neurogenetics have revolutionized the study of consolidation.Providing additional support is the study of functional brain activity in humans which has revealed that the activity of brain regions changes over time after a new memory is acquired.

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Molaison also showed signs of retrograde amnesia spanning a period of about 3 years prior to the surgery suggesting that recently acquired memories of as long as a couple years could remain in the MTL prior to consolidation into other brain areas.

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